The ACAR Laboratory of Systems and Synthetic Biology is interested in understanding how gene network architecture, feedback regulation, and noise in gene expression affect the functioning and evolution of natural and synthetic gene networks.
Using the yeast Saccharomyces cerevisiae as a model organism, we study how gene networks are rewired while cells grow continuously in controlled laboratory environments. Our work combines experimental, theoretical, and computational approaches to investigate general design principles that help gene networks robustly function in a variety of genetic backgrounds and environmental conditions. We utilize microfluidic platforms and chemostats to control the cellular microenvironment.
Read more about our research program.